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TP53 启动子产品信息

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货号 种属 载体 描述 价格 周期
PRO10001 Human pYr-PromDetect (TP53启动子,约1.5K)Homo sapiens tumor protein p53 (TP53), transcript variant 1, mRNA NM_000546
1-2个工作日发货   已测序验证  
4000
3500
现货

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This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

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