PR10376_启动子库_赢润生物-中国最大的基因研究资源库
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货号 种属 载体 描述 价格 周期
PR10376 Mouse pDrive 3500 3-4 周

产品参数

Gene Promoter: Tyr : Tyrosinase
Specificity: Melanocytes & melanoma
Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.

产品说明书

pDRIVE-Tyr / Tyr(mouse) Map 产品说明书(点击下载)

pDRIVE-Tyr / Tyr(mouse) Sequence 产品说明书(点击下载)

产品说明

Description:
Tyrosinase, the rate-limiting enzyme in melanin synthesis, is expressed specifically in pigment-producing cells. Expression of tyrosinase is regulated by cyclic AMP (cAMP). The M-box 70-bp upstream from the TATA-box and the E-box located downstream the TATA-box, near the initiator site, are involved in the regulation of the tyrosinase promoter activity by cAMP [1]. Melanoma-specific expression of a transgene can be achieved by using the tyrosinase promoter [2], this targeted expression being further amplified by addition of the melanocyte-specific enhancer.


1. Bertolotto C. et al. 1996. Regulation of tyrosinase gene expression by cAMP in B16 melanoma cells involves two CATGTG motifs surrounding the TATA box: implication of the microphthalmia gene product. J Cell Biol. 134(3):747-55.
2. Vile R. et al. 1994. Acomparison of the properties of different retroviral vectors containing the murine tyrosinase promoter to achieve transcriptionally targeted expression of the HSVtk or IL-2 genes. Gene Ther. 1(5):307-16.

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