PR10356_启动子库_赢润生物-中国最大的基因研究资源库
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货号 种属 载体 描述 价格 周期
PR10356 Human pGL3-basic 5500 3-4 周

产品参数

Gene Promoter: PSA : Prostate Specific Antigen
Specificity: Prostate and prostate cancers
Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pcDNA3.1-EGFP, ect.

产品说明书

pDRIVE-PSA / PSA(human) Map 产品说明书(点击下载)

产品说明

Description:
Prostate specific antigen (PSA) is a serine protease primarily synthesized by both normal prostate epithelium and the vast majority of prostate cancers. PSA expression is mainly induced by androgens at the transcriptional level via the androgen receptor (AR). The AR modulates transcription through its interaction with its consensus DNA binding site, GGTACAnnnTGTT/CCT, termed the androgen response element (ARE) [1]. The core PSA promoter region exhibits low activity and specificity, but inclusion of the PSA enhancer sequence which contains a putative ARE increases expression, specifically in PSA-positive cells. Expression can be further increased when induced with androgens such as dihydrotestosterone [2].


1. Schuur ER. et al. 1996. Prostate-specific antigen expression is regulated by an upstream enhancer. JBC. 271(12):7043-7051.
2. Latham JP. et al. 2000. Prostate-specific antigenpromoter/enhancer driven gene therapy for prostate cancer: construction and testing of a tissue-specific adenovirus vector. Cancer Res. 60(2):334-41.

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