PR10342_启动子库_赢润生物-中国最大的基因研究资源库
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货号 种属 载体 描述 价格 周期
PR10342 Human pcDNA3.1-EGFP 5500 3-4 周

产品参数

Gene Promoter: L-Plastin (Lymphocyte cytosolic protein 1)
Specificity: Tumor
Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pcDNA3.1-EGFP, ect.

产品说明书

pDRIVE-LP(human) Map 产品说明书(点击下载)

产品说明

Description:
L-plastin (LP) belongs to a family of genes which encode actin-binding proteins. LP is constitutively expressed at high levels in malignant epithelial cells but is not expressed in normal tissues, except at low levels in mature hematopoietic cells. A 315-bp fragment of the 5’ region of the L-plastin gene, spanning the TATAAA box and a potential Sp1-binding site, is sufficient to exhibit strong promoter activity [1]. The L-plastin promoter driving the expression of a suicide gene was used to successfully inhibit the growth of ovarian tumor cells in vitro and in vivo [2].


1. Lin CS. et al. 1993. Characterization of the human L-plastin gene promoter in normal and neoplastic cells. J Biol Chem 268(4):2793-801.
2. Peng XY et al. 2001. The use of the L-plastin promoter for adenoviral-mediated, tumor-specific gene expression in ovarian and bladder cancer cell lines. Cancer Res 61(11):4405-13.

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