PR10332_启动子库_赢润生物-中国最大的基因研究资源库
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货号 种属 载体 描述 价格 周期
PR10332 Human pcDNA3.1-EGFP 3500 3-4 周

产品参数

Gene Promoter: Human Epididymis Protein 4
Specificity: Tumor
Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.

产品说明书

pDRIVE-HE4(human) Map 产品说明书(点击下载)

产品说明

Description:
The human epididymis protein 4 (HE4), a member of the whey-acidic protein family, is frequently overexpressed in ovarian cancer cells. Upregulation of whey-acidic proteins in cancer appears to be due to a transcriptional event. A 652 bp fragment of the HE4 promoter, from -530 to +122 (relative to the ATG start site of HE4), is capable of restricting the expression of a transgene to ovarian tumor cells. The HE4-652 promoter contains a cAMP inducible element and seven Ap1 sites. Several hormonal responsive elements and inflammatory responsive elements are found within the promoter that may contribute to the high expression of HE4 in ovarian cancer.


1. Berry NB. et al., 2004. Transcriptional targeting in ovarian cancer cells using the human epididymis protein 4 promoter. Gynecol Oncol. 92(3):896-904.

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