PR10325_启动子库_赢润生物-中国最大的基因研究资源库
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货号 种属 载体 描述 价格 周期
PR10325 Human pDRIVE5-SEAP 3500 3-4 周

产品参数

Gene Promoter: E2F1 Transcription factor 1
Specificity: Tumor
Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.

产品说明书

pDRIVE-E2F-1(human) Map 产品说明书(点击下载)

pDRIVE5-SEAP-E2F-1(human) Map 产品说明书(点击下载)

pDRIVE5-SEAP-E2F-1(human) Sequence 产品说明书(点击下载)

产品说明

Description:
E2F transcription factors are critical regulators of cell growth and are often overexpressed in cancer cells because of the frequent aberrations in the pRb/E2F/p16(INK4a) pathway. E2F-1 is a transcription factor that activates its own transcription and that of other genes involved in the G(1) to S transition phase of the cell cycle. The E2F-1 promoter was used in an adenovirus to drive the expression of the E1A adenoviral gene and induced selective killing in a variety of tumor cell lines [1].


1. Tsukuda K. et al. 2002. An E2F-responsive replication-selective adenovirus targeted to the defective cell cycle in cancer cells: potent antitumoral efficacy but no toxicity to normal cell. Cancer Res 62(12):3438-47.

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