PR10322_启动子库_赢润生物-中国最大的基因研究资源库
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货号 种属 载体 描述 价格 周期
PR10322 Human pcDNA3.1-EGFP 2500 3-4 周

产品参数

Gene Promoter: CXC-Chemokine receptor 4
Specificity: Tumor
Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.

产品说明书

pDRIVE-CXCR4(human) Map 产品说明书(点击下载)

产品说明

Description:
CXCR4 is the receptor for the chemokine SDF1 and a coreceptor for HIV-1 entry. The expression of CXCR4 is upregulated in many types of cancers but low in the liver and other major organs. The CXCR4 promoter contains a TATAbox, a nuclear respiratory factor-1 (NRF-1) site, and for GC boxes [1].
A 279 bp fragment of the CXCR4 promoter was shown to have a “tumor-on” status in vitro and in vivo particularly in melanoma and breast cancers [2].


1. Moriuchi M. et al., 1997. Cloning and analysis of the promoter region of CXCR4, a coreceptor for HIV-1 entry. J Immunol. 159(9):4322-9.
2. Zhu ZB. et al., 2004. Transcriptional targeting of adenoviral vector through the CXCR4 tumor-specific promoter. Gene Ther. 11(7):645-8.

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