PR10313_启动子库_赢润生物-中国最大的基因研究资源库
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货号 种属 载体 描述 价格 周期
PR10313 Human pcDNA3.1-EGFP 5000 3-4 周

产品参数

Gene Promoter: Cyclo-oxygenase 2 isoform
Specificity: Tumor
Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pcDNA3.1-EGFP, ect.

产品说明书

pDRIVE-COX-2(human) Map 产品说明书(点击下载)

pDRIVE-COX-2(mouse) Map 产品说明书(点击下载)

pDRIVE5-SEAP-COX-2(human) Map 产品说明书(点击下载)

产品说明

Description:
COX-2 is an inducible isoform of cyclooxygenase. Expression of COX-2 is undetectable under physiological conditions but up-regulated in many malignant tumors. COX-2, which is a PKC-dependent gene, is important for the genesis of cancer. COX-2 promoter contains a cAMP response element and sites for AP-2 and NF-κB that are both PKC-responsive cis-elements. COX-2 promoter has been used to target gene expression in pancreatic [1], gastrointestinal [2] and ovarian cancers. Similar levels of expression of luciferase and HSVtk genes were obtained with COX-2 and CMV promoters.


1. Wesseling JG et al. 2001. Midkine and cyclooxygenase-2 promoters are promising for adenoviral vector gene delivery of pancreatic carcinoma. Cancer Gene Ther 8(12):990-6.
2. Yamamoto M et al. 2001. Characterization of the cyclooxygenase-2 promoter in an adenoviral vector and its application for the mitigation of toxicity in suicide gene therapy ofgastrointestinal cancers. Mol Ther. 3(3):385-94.

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