PR10300_启动子库_赢润生物-中国最大的基因研究资源库
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货号 种属 载体 描述 价格 周期
PR10300 Human pUC57 2200 2-3 周

产品参数

Gene Promoter: Carcinoembryonic Antigen
Specificity: Epithelial cancers
Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.

产品说明书

pDRIVE-CEA(human) Map 产品说明书(点击下载)

产品说明

Description:
The carcinoembryonic antigen (CEA) is a cell surface glycoprotein that is overexpressed in colorectal and other cancers of epithelial cell origin. The CEA promoter has been used to induce tumor-selective expression of exogenous genes in human colorectal [1], gastric [2] and lung cancers. In CEA producing cells, the CEA promoter has been shown to be as efficient as the SV40 enhancer/promoter in driving expression of therapeutic genes [1].


1. Cao G. et al. 1998. Comparison of carcinoembryonic antigen promoter regions isolated from human colorectal carcinoma and normal adjacent mucosa to induce strong tumorspecific gene expression. Int J Cancer 78:242-247.
2. Lan KH. et al. 1997. In vivo selective gene expression and therapy mediated by adenoviral vectors for human carcinoembryonic antigen-producing gastric carcinoma. Cancer Res. 57(19):4279-84.

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