PR10294_启动子库_赢润生物-中国最大的基因研究资源库
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货号 种属 载体 描述 价格 周期
PR10294 Human pDRIVE5-SEAP 3500 5-7 周

产品参数

Gene Promoter: Cholecystokinin-A receptor
Specificity: Pancreatic cancer
Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.

产品说明书

pDRIVE-CCKAR(human) Map 产品说明书(点击下载)

产品说明

Description:
Cholecystokinin (CCK) is a gut peptide hormone known to stimulate postprandial gallbladder contraction and pancreatic enzyme secretion. CCK plays also an important role in pancreatic carcinogenesis. The CCK-A receptor (CCKAR) is predominantly expressed in human pancreatic cancer [1]. A 0.7 kb fragment of the CCKAR promoter was reported to drive the expression of the luciferase gene selectively in pancreatic cancer cells and in not normal cells [2]. This fragment lacks a typical TATA box but contains two GC-box motifs [3].


1. Moonka R. et al., 1999. Cholecystokinin-A receptor messenger RNA expression in human pancreatic cancer. J Gastrointest Surg. 3(2):134-40.
2. Li Z. et al., 2005. Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant. Cancer Lett. 236(1):58-63.
3. Takata Y,. et al., 2002. Promoter analysis of human cholecystokinin type-A receptor gene. J Gastroenterol. 37(10):815-20.

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