PR10280_启动子库_赢润生物-中国最大的基因研究资源库
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货号 种属 载体 描述 价格 周期
PR10280 Human pGL3-basic 3000 3-4 周

产品参数

Gene Promoter: Wiskott-Aldrich Syndrom Protein
Specificity: Hematopoietic cells
Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.

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Description:
Wiskott-Aldrich syndrome protein (WASP) is a major cytoskeletal regulator expressed in hematopoietic cells. Mutations in the WASP gene result in an immune deficiency with thrombocytopenia. A 500 bp fragment from the proximal WASP gene promoter (extending from bases -1 to -499 from the transcriptional start site) was shown to direct hematopoietic-specific expression of a transgene [1]. This fragment contains four potential binding sites for hematopoietic transcription factors (two for ets-1, one for c-Rel, and one for PU.1). Transduction of WASP-deficient cells with a lentiviral expressing the WASP gene under the control of the proximal WASP gene promoter resulted in physiological levels of WASP expression [2]. The WASP expression levels were 135-350 times lower in non-hematopoietic cells.


1. Petrella A. et al., 1998. A 5' regulatory sequence containing two Ets motifs controls the expression of the Wiskott-Aldrich syndrome protein (WASP) gene in human hematopoietic cells. Blood. 91(12):4554-60.
2. Martin F. et al., 2005. Lentiviral vectors transcriptionally targeted to hematopoietic cells by WASP gene proximal promoter sequences. Gene Ther. 12(8):715-23.

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