PR10272_启动子库_赢润生物-中国最大的基因研究资源库
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货号 种属 载体 描述 价格 周期
PR10272 Human pDRIVE5-SEAP 3500 3-4 周

产品参数

Gene Promoter: Synapsin I
Specificity: Neurons
Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.

产品说明书

pDRIVE-SYN1(human) Map 产品说明书(点击下载)

pDRIVE-SYN1(human) Sequence 产品说明书(点击下载)

pDRIVE5-SEAP-SYN1(human) Map 产品说明书(点击下载)

pDRIVE5-SEAP-SYN1(human) Sequence 产品说明书(点击下载)

产品说明

Description:
Synapsin I is a neuron-specific phosphoprotein that coats the cytoplasmic surface of small synaptic vesicles. The proximal region of the synapsin I promoter (-422 to -22) is sufficient to direct neuron-specific gene expression. Neuron specificity is conferred by a putative binding site for the zinc finger protein, neuron-restrictive silencer factor/RE-1 silencing transcription factor (NRSF/REST). The NRSF/REST protein, which is expressed only in non-neuronal cells, represses the activity of constitutive enhancers thus silencing the expression of synapsin I in non-neuronal cells [1]. The synapsin I promoter has been used to achieve highly neuron-specific long-term transgene expression in vivo [2].


1. Schoch S. et al., 1996. Neuron-specific gene expression of synapsin I. Major role of a negative regulatory mechanism. J Biol Chem. 271(6):3317-23.
2. Kugler S. et al., 2003. Human synapsin 1 gene promoter confers highly neuron-specific long-term transgene expression from an adenoviral vector in the adult rat brain depending on the transduced area. Gene Ther. 10(4):337-47.

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