PR10259_启动子库_赢润生物-中国最大的基因研究资源库
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货号 种属 载体 描述 价格 周期
PR10259 Rattus pDrive 3500 3-4 周

产品参数

Gene Promoter: NSE : Neuron-Specific Enolase
Specificity: Mature neurons
Backbone: pDRIVE, pDRIVE5-SEAP, ect.

产品说明书

pDRIVE-NSE / RU5'(rat) Map 产品说明书(点击下载)

pDRIVE5-SEAP-NSE / RU5'(rat) Map 产品说明书(点击下载)

pDRIVE5-SEAP-NSE / RU5'(rat) Sequence 产品说明书(点击下载)

产品说明

Description:
Neuron-specific enolase, an isoenzyme form of enolase, occurs in mature neurons and paraneurons. Transgenic mouse studies have shown that a 1.8 kb fragment of the rat NSE promoter is able to express a heterologous gene exclusively in postmitotic neurons and neuro-endocrine cells in parallel with endogenous NSE [1]. The NSE promoter contains a TATA-like sequence, no CAAT box and sequences for the AP-1 binding motif, AP-2 binding element, SP-1 binding sequence and cAMP response element [2]. The NSE promoter was used to create transgenic mice exhibiting the neuropathological phenotypes of Alzheimer's disease [3].


1. Forss-Petter S. et al. 1990. Transgenic mice expressing beta-galactosidase in mature neurons under neuron-specific enolase promoter control. Neuron 5(2):187-97.
2. Sakimura K. et al. 1995. Upstream and intron regulatory regions for expression of the rat neuron-specific enolase gene. Brain Res Mol B 28(1):19-28.
3. Hwang DY. et al., 2004. Aberrant expressions of pathogenic phenotype in Alzheimer's diseased transgenic mice carrying NSE-controlled APPsw. Exp Neurol. 186(1):20-32.

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