PR10246_启动子库_赢润生物-中国最大的基因研究资源库
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货号 种属 载体 描述 价格 周期
PR10246 Human pDrive 3500 3-4 周

产品参数

Gene Promoter: Myoglobin
Specificity: Muscle
Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.

产品说明书

pDRIVE-Myoglobin(human&mouse) Map 产品说明书(点击下载)

pDRIVE5-SEAP-Myoglobin(human) Map 产品说明书(点击下载)

pDRIVE5-SEAP-Myoglobin(human) Sequence 产品说明书(点击下载)

产品说明

Description:
Myoglobin is a cytoplasmic hemoprotein that binds molecular oxygen to facilitate its diffusion from the vascular system to the muscle mitochondria. Myoglobin is found only in muscle, predominantly in cardiac and skeletal myocytes. The myoglobin promoter can drive the expression of a transgene in multinucleated myotubes but not in mononucleated and undifferentiated cells [1]. This capacity is conferred by a small segment of the 5’ flanking region extending from nucleotides -357 to +55 relative to the transcriptional start site [2].


1. Devlin BH. et al. 1989. Identification of a muscle-specific enhancer within the 5’-flanking region of the human myoglobin gene. J Biol Chem 264(23):13896-13901.
2. Yan Z. et al. 2001. Regulatory elements governing transcription in specialized myofiber subtypes. J Biol Chem 276(20):17361-17366.

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