PR10238_启动子库_赢润生物-中国最大的基因研究资源库
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货号 种属 载体 描述 价格 周期
PR10238 Human pUC57 1600 现货

产品参数

Gene Promoter: Intracellular Adhesion Molecule 2
Alias: CD102
Specificity: Endothelial cells
Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.

产品说明书

pDRIVE-ICAM-2(human) Map 产品说明书(点击下载)

pDRIVE5-SEAP-ICAM-2(human) Map 产品说明书(点击下载)

pDRIVE5-SEAP-ICAM-2(human) Sequence 产品说明书(点击下载)

产品说明

Description:
ICAM-2 is a cell surface adhesion molecule constitutively expressed in vasculature endothelial cells and megakaryocytes. Endothelial-specific activity of the ICAM-2 promoter resides in a 334 bp fragment in the 5’ flanking region of the gene [1]. The promoter contains no TATA box but four transcription factor binding sites such as Sp1 and GATA motifs, essential for basal and endothelial-specific expression of the ICAM-2 gene. The ICAM-2 promoter has been used to generate transgenic animals which demonstrated endothelial expression of a transgene [2,3].


1. Cowan PJ. et al., 1998. The human ICAM-2 promoter is endothelial cell-specific in vitro and in vivo and contains critical Sp1 and GATA binding sites. J Biol Chem. 273(19):11737-44.
2. Cowan PJ. et al., 1996. Targeting gene expression to endothelial cells in transgenic mice using the human intercellular adhesion molecule 2 promoter. Transplantation. 62(2):155-60.
3. Velasco B. et al.,. 2001. Vascular gene transfer driven by endoglin and ICAM-2 endothelial-specific promoters. Gene Ther. 8(12):897-904.

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