PR10220_启动子库_赢润生物-中国最大的基因研究资源库
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货号 种属 载体 描述 价格 周期
PR10220 Human pcDNA3.1-EGFP 5000 5-7 周

产品参数

Gene Promoter: VEGF Receptor 1
Specificity: Endothelial cells
Backbone: pDRIVE, pDRIVE5-SEAP, pcDNA3.1-EGFP, pGL3-basic, ect.

产品说明书

pDRIVE-Flt-1(human) Map 产品说明书(点击下载)

产品说明

Description:
The fms-like tyrosine kinase Flt-1 is one of the receptors for VEGF. Flt-1 is expressed specifically in endothelial cells and up-regulated in tumor vasculature. The promoter region contains a TATA box, a GC-rich region, nine Ets motifs and one CRE motif, located in a 489 bp fragment upstream of exon-1 [1]. This region is essential for basal and cell-type specific expression of the Flt-1 gene [2]. The Flt-1 promoter has been used to generate high levels of transgene expression targeted to endothelial cells in vitro and in vivo [3].


1. Morishita K. et al., 1995. A novel promoter for vascular endothelial growth factor receptor (flt-1) that confers endothelial-specific gene expression. J Biol Chem. 270(46):27948-53.
2. Wakiya K. et al., 1996. AcAMP response element and an Ets motif are involved in the transcriptional regulation of flt-1 tyrosine kinase (vascular endothelial growth factor receptor 1) gene. J Biol Chem. 1996 Nov 29;271(48):30823-8.
3. Nicklin SA. et al., 2001. Analysis of cell-specific promoters for viral gene therapy targeted at the vascular endothelium. Hypertension. 38(1):65-70.

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