PR10209_启动子库_赢润生物-中国基因研究资源库
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货号 种属 载体 描述 价格 周期
PR10209 Rattus pGL3-basic 2500 1-2 周

产品参数

Gene Promoter: Elastase-1
Specificity: Pancreatic acinar cells
Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.

产品说明书

pDRIVE-Elastase-1(rat) Map 产品说明书(点击下载)

pDRIVE5-SEAP-Elastase-1(rat) Map 产品说明书(点击下载)

产品说明

Description:
The elastase gene is one of the pancreatic digestive enzyme genes which is activated in a stage- and site- specific manner during development of the mammalian gut. The rat elastase 1 promoter is a 213 bp fragment comprised of the core promoter (-72 to +8) and the enhancer (-205 to -73). The elastase 1 promoter was shown to direct the expression of a human growth hormone transgene in pancreatic acinar cells, stomach, duodenum, and colon. This pattern of selective expression limited to the gastroenteropancreatic organ system is specified by the A element, one of three functional elements in the elastase 1 enhancer.


1. Ornitz DM. et al. 1985. Specific expression of an elastase-human growth hormone fusion gene in pancreatic acinar cells of transgenic mice. Nature 313(6003):600-2.
2. Rose SD. et al. 1994. A single element of the elastase I enhancer is sufficient to direct transcription selectively to the pancreas and gut. Mol Cell Biol 14(3):2048-57.

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