PR10176_启动子库_赢润生物-中国基因研究资源库
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货号 种属 载体 描述 价格 周期
PR10176 Human pGL3-basic 4000 3-4 周

产品参数

Gene Promoter: Monocyte Receptor for Bacterial LPS
Specificity: Monocytic cells
Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.

产品说明书

pDRIVE-CD14(human) Map 产品说明书(点击下载)

pDRIVE5-SEAP-CD14(human) Map 产品说明书(点击下载)

pDRIVE5-SEAP-CD14(human) Sequence 产品说明书(点击下载)

产品说明

Description:
CD14 is a receptor for bacterial lipopolysaccharide expressed on the surface of myeloid-derived cells, and is strongly upregulated during monocytic cell differentiation. Monocyte-specific expression of CD14 is regulated at the transcriptional level. The CD14 promoter contains a C/EBP [1] and Sp1 [2] site that are critical for tissue-specific regulation of CD14 gene expression.


1. Pan Z. et al. 1999. CCAAT/enhancer-binding protein activates the CD14 promoter and mediates transforming growth factor beta signaling in monocyte development. J Biol Chem 274(33):23242-8.
2. Park S. et al. 2002. Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter. Mol Immunol 39(1-2):25.

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