PR10133_启动子库_赢润生物-中国基因研究资源库
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货号 种属 载体 描述 价格 周期
PR10133 Mouse pcDNA3.1-EGFP 5000 5-7 周

产品参数

Gene Promoter: PGK-1
Specificity: Ubiquitous
Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.

产品说明书

pDRIVE-PGK-1(mouse) Map 产品说明书(点击下载)

pDRIVE-PGK-1(mouse) Sequence 产品说明书(点击下载)

pDRIVE5-SEAP-PGK-1(mouse) Map 产品说明书(点击下载)

pDRIVE5-SEAP-PGK-1(mouse) Sequence 产品说明书(点击下载)

产品说明

Description:
Pgk-1 is an X-linked gene encoding 3-phosphoglycerate kinase, an enzyme necessary in every cell for glycolysis. The promoter region of the pgk-1 gene is rich in G and C nucleotides and contains five copies of the hexadeoxynucleotide, GGGCGG, a potential binding site for the Sp1 transcription factor, a CCAAT sequence, but no TATA box [1]. This promoter can efficiently drive high levels of expression of reporter genes (i.e. LacZ and GFP) and therapeutic genes, such as tumor-associated antigenes [2, 3]. Furthermore, in contrast to the CMV promoter, the PGK promoter yields sustained expression [2].


1. Adra CN. et al. 1987. Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter. Gene 60(1):65-74.
2. Gerolami R. et al. 2000. Gene transfer to hepatocellular carcinoma: transduction efficacy and transgene expression kinetics by using retroviral and lentiviral vectors. Cancer Gene Ther 7(9):1286-92.
3. Lizee G. et al., 2004. Lentivirus vector-mediated expression of tumor-associated epitopes by human antigen presenting cells. Hum Gene Ther. 15(4):393-404.

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