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货号 种属 载体 描述 价格 周期
PR10117 Human pUC57 2000 2-3 周


Gene Promoter: Heat Shock Protein 70
Specificity: Ubiquitous, heat inducible
Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.


pDRIVE-HSP70(human&mouse) Map 产品说明书(点击下载)

pDRIVE-HSP70(human) Sequence 产品说明书(点击下载)

pDRIVE-HSP70(mouse) Sequence 产品说明书(点击下载)

pDRIVE5-SEAP-HSP70(human) Map 产品说明书(点击下载)

pDRIVE5-SEAP-HSP70(human) Sequence 产品说明书(点击下载)


Heat inducible
The HSP70 gene encodes a major stress-inducible heat shock protein (HSP70) which plays an important role in protecting cells from deleterious stresses. Hsp70 is expressed constitutively in a wide variety of cells at normal growth temperatures. Its expression is induced by various physiological stresses, including exposure to heat shock and heavy metal, or under nonstress conditions, such as in response to serum stimulation. The HSP70 promoter contains at least two regulatory domains, a distal domain responsive to heat shock or heavy metals and a proximal domain responsive to stimulation by serum [1]. The activity of the HSP70 promoter can be induced by moderate hyperthermia (39°C to 43°C) [2], reaching expression levels similar to those of the CMV promoter.

1. Wu BJ. Kingston RE, Morimoto RI. 1986. Human HSP70 promoter contains at least two distinct regulatory domains. Proc Natl Acad Sci USA. 83(3):629-33.
2. Huang Q. et al. 2000. Heat-induced gene expression as a novel targeted cancer gene therapy strategy. Cancer Res. 60(13):3435-9.

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