PR10081_启动子库_赢润生物-中国基因研究资源库
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货号 种属 载体 描述 价格 周期
PR10081 Human pGL3-basic 4000 3-4 周

产品参数

Gene Promoter: Glyceraldehyde 3-Phosphate Dehydrogenase
Specificity: Ubiquitous
Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.

产品说明书

pDRIVE-GAPDH(human) Map 产品说明书(点击下载)

pDRIVE-GAPDH(human) Sequence 产品说明书(点击下载)

产品说明

Description:
Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is a catalytic enzyme involved in glycolysis. The GAPDH gene is constitutively expressed at high levels in almost all tissues. However, the molecular mechanism which sustains high-level expression of this ’housekeeping’ enzyme is still unclear.
The expression of GAPDH can be induced by several physiological factors in certain cell types. In adipocytes, insulin increases the levels of GAPDH mRNA through cis-acting sequences located within the GAPDH promoter [1]. In endothelial cells, GAPDH is induced by hypoxia at the transcriptional level, this upregulation occuring to a much greater extent in EC than in other cell types [2].


1. Ercolani L. et al. 1988. Isolation and complete sequence of a functional human glyceraldehyde-3-phosphate dehydrogenase gene. J Biol Chem. 263(30):15335-41.
2. Graven KK. et al. 1999. Identification of an oxygen responsive enhancer element in the glyceraldehyde-3-phosphate dehydrogenase gene. Biochim Biophys Acta. 1447(2-3):208-18.

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