rAd032416_过表达腺病毒库_赢润生物-中国基因研究资源库
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大鼠 ALDH2 (NM_032416) 过表达腺病毒产品信息

订购信息

货号 种属 载体 描述 荧光 价格 周期
rAd032416 Rattus 腺病毒 Rattus norvegicus aldehyde dehydrogenase 2 family (mitochondrial)(Aldh2),mRNA NM_032416 带绿色荧光 8500
8000
6-7 周

基本信息

基因名称: ALDH2
NCBI序列号: NM_032416
基因描述: Rattus norvegicus aldehyde dehydrogenase 2 family (mitochondrial)(Aldh2),mRNA NM_032416
基因种属: Rattus
荧光标记: 带绿色荧光
腺病毒滴度: 109~1010pfu/ml

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基因简介

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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